Andres Benzaquen

Treatment-Resistant Depression: Why Mental Health Care Must Move Beyond Trial and Error

Depression is one of the most common and challenging health conditions in the world. But for many people, the hardest part is not getting diagnosed. It is discovering that the first treatment—or even the second—does not work well enough. This reality is often described as treatment-resistant depression (TRD). Treatment-resistant depression is more than a clinical term. It reflects a broader problem in mental health care: too many patients still move through treatment in a trial-and-error proce