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Uses
Side effects
Interactions
Precautions
- LIPITOR is an inhibitor of HMG-CoA reductase (statin) indicated as an Liver enzyme abnormalities and monitoring: Persistent elevations in hepatic adjunct therapy to diet to: transaminases can occur. Monitor liver enzymes before and during treatment
- Â Reduce the risk of MI, stroke, revascularization procedures, and angina (5.2). in patients without CHD, but with multiple risk factors (1.1).
- Reduce the risk of MI and stroke in patients with type 2 diabetes without A higher incidence of hemorrhagic stroke was seen in patients without CHD CHD, but with multiple risk factors (1.1). but with stroke or TIA within the previous 6 months in the LIPITOR 80 mg
- Â Reduce the risk of non-fatal MI, fatal and non-fatal stroke, group vs. placebo (5.5). revascularization procedures, hospitalization for CHF, and angina in patients with CHD (1.1).
- The most commonly reported adverse reactions (incidence ≥ 2%) in patients ary hyperlipidemia (heterozygous treated with LIPITOR in placebo-controlled trials regardless of causality familial and nonfamilial) and mixed dyslipidemia (1.2). were: nasopharyngitis, arthralgia, diarrhea, pain in extremity, and urinary tract
- Â Reduce elevated TG in patients with hypertriglyceridemia and primary infection (6.1)
- Drug Interactions Associated with Increased Limitations of Use Interacting Agents Prescribing Recommendations Cyclosporine Do not exceed 10 mg atorvastatin daily Clarithromycin, itraconazole, HIV protease inhibitors (ritonavir plus saquinavir or lopinavir plus ritonavir) Caution when exceeding doses > 20 mg atorvastatin daily.
- The lowest dose necessary should be used. Risk of Myopathy/Rhabdomyolysis (2.6, 5.1, 7, 12.3) LIPITOR has not been studied in Fredrickson Types I and V dyslipidemias.
- Skeletal muscle effects (e.g., myopathy and rhabdomyolysis): Risks increase LIPITOR safely and effectively. See full prescribing information for when higher doses are used concomitantly with cyclosporine, fibrates, and LIPITOR. strong CYP3A4 inhibitors (e.g., clarithromycin, itraconazole, HIV protease inhibitors).
- Predisposing factors include advanced age (> 65), uncontrolled LIPITOR® (atorvastatin calcium) Tablets for oral administration hypothyroidism, and renal impairment.
- Rare cases of rhabdomyolysis with Initial U.S. Approval: 1996 acute renal failure secondary to myoglobinuria have been reported. In cases of myopathy or rhabdomyolysis, therapy should be temporarily withheld or discontinued (5.1).
