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Uses
Side effects
Interactions
Precautions
- ONFI is a benzodiazepine indicated for adjunctive treatment of seizures associated with Lennox-Gastaut syndrome (LGS) in patients 2 years of age or older
- Adverse reactions that occurred at least 10% more frequently than placebo in any ONFI dose included constipation, somnolence or sedation, pyrexia, lethargy, and drooling
- Alcohol: Increases blood levels of clobazam by about 50%
- Drugs metabolized by CYP2D6: Lower doses of these drugs may be required when used concomitantly with ONFI
- Strong or Moderate CYP2C19 Inhibitors: Dosage adjustment of ONFI may be necessary
- Somnolence or Sedation: Monitor for central nervous system (CNS) depression. Risk may be increased with concomitant use of other CNS depressants
- Withdrawal: Symptoms may occur with rapid dose reduction or discontinuation. Discontinue ONFI gradually
- Serious Dermatological Reactions (including Stevens-Johnson syndrome and toxic epidermal necrolysis): Discontinue ONFI at first sign of rash unless the rash is clearly not drug-related
- Physical and Psychological Dependence: Monitor patients with a history of substance abuse for signs of habituation and dependence
- Suicidal Behavior and Ideation: Monitor for suicidal thoughts or behaviors
