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Uses
Side effects
Interactions
Precautions
- AMRIX is a muscle relaxant indicated as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions.
- Limitations of Use:
- AMRIX should be used only for short periods (up to 2 or 3 weeks)
- AMRIX has not been found effective in the treatment of spasticity or cerebral palsy
- Most common adverse reactions (incidence ≥3% in any treatment group and greater than placebo): dry mouth, dizziness, fatigue, constipation, nausea, dyspepsia, and somnolence
- MAO Inhibitors: Life-threatening interactions may occur
- Serotonergic Drugs: Serotonin syndrome has been reported
- CNS Depressants: Effects of alcohol, barbiturates, and other CNS depressants may be enhanced
- Tramadol: Seizure risk may be enhanced
- Guanethidine: Antihypertensive effect may be blocked
- Serotonin syndrome has been reported with cyclobenzaprine when used in combination with other serotonergic drugs
- Cyclobenzaprine is structurally related to tricyclic antidepressants which have been reported to produce adverse cardiovascular effects or CNS depressant effects
- Use in the elderly is not recommended
- Use in patients with hepatic impairment is not recommended
- Use with caution in patients with a history of urinary retention, angle-closure glaucoma, increased intraocular pressure and in patients taking anticholinergic medications