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Uses
Side effects
Interactions
Precautions
How Pristiq (Desvenlafaxine) works
- PRISTIQ, a selective serotonin and norepinephrine reuptake inhibitor (SNRI).
- it is indicated for the treatment of Major Depressive Disorder.
What are the side effects of Pristiq (Desvenlafaxine)?
Adverse reactions in patients in short-term fixed-dose studies (incidence ≥ 5% and twice the rate of placebo in the 50 or 100 mg dose groups) were:
- nausea
- dizziness
- insomnia
- hyperhidrosis
- constipation
- somnolence
- decreased appetite
- anxiety
- specific male sexual function disorders
- Clinical studies have shown that desvenlafaxine does not have a clinically relevant effect on CYP2D6 metabolism at the dose of 100 mg daily.
- When desvenlafaxine succinate was administered at a dose of 100 mg daily in conjunction with a single 50 mg dose of desipramine, a CYP2D6 substrate, the Cmax and AUC of desipramine increased approximately 25% and 17%, respectively. When 400 mg (8 times the recommended 50 mg dose) was administered, the Cmax and AUC of desipramine increased approximately 50% and 90%, respectively.
- Concomitant use of desvenlafaxine with a drug metabolized by CYP2D6 can result in higher concentrations of that drug.
- Clinical Worsening/Suicide Risk: Monitor for clinical worsening and suicide risk
- Serotonin Syndrome or Neuroleptic Malignant Syndrome (NMS)-like Reactions: Serotonin syndrome or NMS-like reactions have been reported with SSRIs and SNRIs. Discontinue PRISTIQ and initiate supportive treatment
- Elevated Blood Pressure: Has occurred with PRISTIQ. Hypertension should be controlled before initiating treatment. Monitor blood pressure regularly during treatment
- Abnormal Bleeding: PRISTIQ may increase the risk of bleeding events. Patients should be cautioned about the risk of bleeding associated with the concomitant use of PRISTIQ and NSAIDs, aspirin, or other drugs that affect coagulation
- Narrow-angle Glaucoma: Mydriasis has occurred with PRISTIQ. Patients with raised intraocular pressure or those at risk of angle-closure glaucoma should be monitored
- Activation of Mania/Hypomania: Has occurred. Use cautiously in patients with Bipolar Disorder. Caution patients about the risk of activation of mania/hypomania
- Cardiovascular/Cerebrovascular Disease: Use cautiously in patients with cardiovascular or cerebrovascular disease
- Cholesterol and Triglyceride Elevation: Have occurred. Use cautiously in patients with lipid metabolism disorders. Consider monitoring serum cholesterol and triglyceride
- Discontinuation Symptoms: Have occurred. Taper the dose when possible and monitor for discontinuation symptoms
- Renal Impairment: Reduces the clearance of PRISTIQ. Dosage adjustment is necessary in severe and ESRD. In moderate renal impairment, the dose should not exceed 50 mg/day
- Seizure: Can occur. Use cautiously in patients with seizure disorder
- Hyponatremia: Can occur in association with SIADH
- Drugs Containing Desvenlafaxine or Venlafaxine: Should not be used concomitantly with PRISTIQ
- Interstitial Lung Disease and Eosinophilic Pneumonia: Can occur
