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Uses
Side effects
Interactions
Precautions
- POTIGA is a potassium channel opener indicated as adjunctive treatment of partial-onset seizures in patients aged 18 years and older.
- The most common adverse reactions (incidence 4% and approximately twice placebo) are dizziness, somnolence, fatigue, confusional state, vertigo, tremor, abnormal coordination, diplopia, disturbance in attention, memory impairment, asthenia, blurred vision, gait disturbance, aphasia, dysarthria, and balance disorder.
- Ezogabine plasma levels may be reduced by concomitant administration of phenytoin or carbamazepine. An increase in dosage of POTIGA should be considered when adding phenytoin or carbamazepine.
- N-acetyl metabolite of ezogabine may inhibit renal clearance of digoxin, a P-glycoprotein substrate. Monitor digoxin levels.
- Urinary retention: Patients should be carefully monitored for urologic symptoms.
- Neuropsychiatric symptoms: Monitor for confusional state, psychotic symptoms, and hallucinations.
- Dizziness and somnolence: Monitor for dizziness and somnolence.
- QT prolongation: QT interval should be monitored in patients taking concomitant medications known to increase the QT interval or with certain heart conditions.
- Suicidal behavior and ideation: Monitor for suicidal thoughts or behaviors.
