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Uses
Side effects
Interactions
Precautions
- CEREBYX is indicated for the treatment of generalized tonic-clonic status epilepticus and prevention and treatment of seizures occurring during neurosurgery.
- CEREBYX can also be substituted, as short-term use, for oral phenytoin.
- CEREBYX should be used only when oral phenytoin administration is not possible.
- Most common adverse reactions (incidence ≥10%) are: Adults: pruritus, nystagmus, dizziness, somnolence, and ataxia Pediatrics: vomiting, nystagmus, and ataxia
- Multiple drug interactions because of extensive plasma protein binding, saturable metabolism, and potent induction of hepatic enzymes
- Dosing Errors: Do not confuse the amount of drug to be given in PE with the concentration of the drug in the vial. Ensure the appropriate volume is withdrawn from the vial when preparing for administration.
- Withdrawal Precipitated Seizure: May precipitate status epilepticus. Dose reductions or discontinuation should be done gradually.
- Serious Dermatologic Reactions: Discontinue at the first sign of a rash, unless clearly not drug-related. If signs or symptoms suggest SJS/TEN, CEREBYX should not be resumed; consider alternative therapy.
- Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)/Multiorgan hypersensitivity: If signs or symptoms of hypersensitivity are present, evaluate the patient immediately. Discontinue if an alternative etiology cannot be established.
- Hematopoietic Complications: If occurs, follow-up observation is indicated and an alternative antiepileptic treatment should be used.
