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- PREVACID is a proton pump inhibitor (PPI).
- Most commonly reported adverse reactions (≥1%): diarrhea, abdominal pain, nausea and constipation. (6)
Atazanavir: Do not co-administer with atazanavir. (7.1)
• Drugs with pH-Dependent Absorption: May interfere with the absorption of drugs where gastric pH is important for bioavailability. (7.1)
• Warfarin: Concomitant warfarin use may require monitoring for increases in INR and prothrombin time. (7.2)
• Tacrolimus: Concomitant tacrolimus use may increase tacrolimus whole blood concentrations. (7.3)
• Theophylline: Titration of theophylline dosage may be required when concomitant PREVACID use is started or stopped. (7.4)
• Methotrexate: PREVACID may increase serum levels of methotrexate. (7.6)
Symptomatic response with PREVACID does not preclude the presence of gastric malignancy. (5.1)
• PPI therapy may be associated with increased risk of Clostridium difficile associated diarrhea. (5.2)
• Bone Fracture: Long-term and multiple daily dose PPI therapy may be associated with an increased risk for osteoporosis-related fractures of the hip, wrist or spine. (5.3)
• Hypomagnesemia has been reported rarely with prolonged treatment with PPIs. (5.4)
