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COZAAR is an angiotensin II receptor blocker (ARB) indicated for:
• Treatment of hypertension, to lower blood pressure in adults and children greater than 6 years old. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular events, primarily strokes and myocardial infarctions. (1.1)
• Reduction of the risk of stroke in patients with hypertension and left ventricular hypertrophy. There is evidence that this benefit does not apply to Black patients. (1.2)
• Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria in patients with type 2 diabetes and a history of hypertension. (1.3)
- Most common adverse reactions (incidence ≥2% and greater than placebo) are: dizziness, upper respiratory infection, nasal congestion, and back pain. (6.1)
Agents increasing serum potassium: Risk of hyperkalemia. (7.1)
• Lithium: Risk of lithium toxicity. (7.2)
• NSAIDs: Increased risk of renal impairment and reduced diuretic, natriuretic, and antihypertensive effects. (7.3)
• Dual inhibition of the renin-angiotensin system: Increased risk of renal impairment, hypotension, syncope, and hyperkalemia. (7.4)
Hypotension: Correct volume or salt depletion prior to administration of COZAAR. (5.2)
• Monitor renal function and potassium in susceptible patients. (5.3, 5.4)
