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Uses
Side effects
Interactions
Precautions
- Metoprolol succinate extended-release capsules are beta1-selective adrenoceptor blocking agents indicated for the treatment of:
- Hypertension, to lower blood pressure. Lowering blood pressure reduces the risk of fatal and non-fatal cardiovascular events, primarily strokes and myocardial infarctions. (1.1)
- Angina Pectoris. (1.2)
- Heart Failure, to reduce the risk of cardiovascular mortality and heart-failure hospitalization in patients with heart failure. (1.3)
- Most common adverse reactions: tiredness, dizziness, depression, shortness of breath, bradycardia, hypotension, diarrhea, pruritus, rash. (6.1)
- Catecholamine-depleting drugs may have an additive effect when given with beta-blocking agents. (7.1)
- Patients may be unresponsive to the usual doses of epinephrine used to treat allergic reaction. (7.2)
- CYP2D6 Inhibitors are likely to increase metoprolol concentration. (7.3)
- Concomitant use of glycosides, clonidine, and diltiazem and verapamil with beta-blockers can increase the risk of bradycardia. (7.4)
- Beta-blockers including metoprolol, may exacerbate the rebound hypertension that can follow the withdrawal of clonidine. (7.4)
- Alcohol interferes with the extended release properties of this product. (7.5)
Abrupt cessation may exacerbate myocardial ischemia. (5.1)
- Worsening cardiac failure may occur. (5.2)
- Bronchospastic Disease: Avoid beta blockers. (5.3)
- Pheochromocytoma: First initiate therapy with an alpha blocker. (5.4)
- Avoid initiation of high-dose extended-release metoprolol and do not routinely withdraw chronic beta blocker therapy prior to surgery. (5.5, 6.1)
- May mask tachycardia occurring with hypoglycemia. (5.6)
- Abrupt withdrawal in thyrotoxicosis might precipitate a thyroid storm. (5.7)
- May aggravate symptoms of arterial insufficiency. (5.8)
