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Uses
Side effects
Interactions
Precautions
How Zoloft (Sertaline) works
ZOLOFT is a selective serotonin reuptake inhibitor (SSRI) indicated for the treatment of:
- Major depressive disorder (MDD)
- Obsessive-compulsive disorder (OCD)
- Panic disorder (PD)
- Post-traumatic stress disorder (PTSD)
- Social anxiety disorder (SAD)
- Premenstrual dysphoric disorder (PMDD)
What are the side effects of Zoloft (Sertaline)?
Most common adverse reactions (>5% and twice placebo) in pooled placebocontrolled MDD, OCD, PD, PTSD, SAD and PMDD clinical trials were nausea:
- diarrhea/loose stool
- tremor
- dyspepsia
- decreased appetite
- hyperhidrosis
- ejaculation failure
- and decreased libido
- Protein-bound drugs: Monitor for adverse reactions and reduce dosage of ZOLOFT or other protein-bound drugs (e.g., warfarin) as warranted.
- CYP2D6 substrates: Reduce dosage of drugs metabolized by CYP2D6
- Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents (e.g., SSRI, SNRI, triptans), but also when taken alone. If it occurs, discontinue ZOLOFT and initiate supportive treatment.
- Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal antiinflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk.
- Activation of Mania/Hypomania: Screen patients for bipolar disorder.
- Seizures: Use with caution in patients with seizure disorders.
- Angle Closure Glaucoma: Avoid use of antidepressants, including ZOLOFT, in patients with untreated anatomically narrow angles.
