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How Desyrel – Trazodone works
- DESYREL is a selective serotonin reuptake inhibitor indicated for the treatment of major depressive disorder (MDD).
What are the side effects of Desyrel – Trazodone?
- edema,
- blurred vision,
- syncope,
- drowsiness,
- fatigue,
- diarrhea,
- nasal congestion, weight loss (6).
• CNS Depressants: DESYREL may enhance effects of alcohol, barbiturates, or other CNS depressants
• CYP3A4 Inhibitors: Consider DESYREL dose reduction based on tolerability
• CYP3A4 Inducers: Increase in DESYREL dosage may be necessary
• Digoxin or Phenytoin: Monitor for increased digoxin or phenytoin serum levels
• Warfarin: Monitor for increased or decreased prothrombin time.
• Serotonin Syndrome: Increased risk when co-administered with other serotonergic agents (e.g., SSRI, SNRI, triptans), but also when taken alone. If it occurs, discontinue DESYREL and initiate supportive treatment
• Cardiac Arrhythmias: Increases the QT interval. Avoid use with drugs that also increase the QT interval and in patients with risk factors for prolonged QT interval
• Orthostatic Hypotension and Syncope: Warn patients of risk and symptoms of hypotension.
• Increased Risk of Bleeding: Concomitant use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), other antiplatelet drugs, warfarin, and other anticoagulants may increase this risk
• Priapism: Cases of painful and prolonged penile erections and priapism have been reported. Immediate medical attention should be sought if signs and symptoms of prolonged penile erections or priapism are observed
• Activation of Mania or Hypomania: Screen for bipolar disorder and monitor for mania or hypomania
• Potential for Cognitive and Motor Impairment: Has potential to impair judgment, thinking, and motor skills. Advise patients to use caution when operating machinery
• Angle-Closure Glaucoma: Avoid use of antidepressants, including DESYREL, in patients with untreated anatomically narrow angles..
