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Uses
Side effects
Interactions
Precautions
How Trintellix works
- TRINTELLIX is indicated for the treatment of major depressive disorder (MDD) in adults. The recommended starting dose is 10 mg administered orally once daily without regard to meals. The dose should then be increased to 20 mg/day, as tolerated. Consider 5 mg/day for patients who do not tolerate higher doses. TRINTELLIX can be discontinued abruptly. However, it is recommended that doses of 15 mg/day or 20 mg/day be reduced to 10 mg/day for one week prior to full discontinuation if possible
- Most common adverse reactions (incidence ≥5% and at least twice the rate of placebo) were: nausea, constipation and vomiting (6).
- Strong inhibitors of CYP2D6: Reduce TRINTELLIX dose by half when a strong CYP2D6 inhibitor (e.g., bupropion, fluoxetine, paroxetine, or quinidine) is coadministered.
- Strong CYP Inducers: Consider increasing TRINTELLIX dose when a strong CYP inducer (e.g., rifampin, carbamazepine, or phenytoin) is coadministered for more than 14 days.
- The maximum recommended dose should not exceed 3 times the original dose.
- Serotonin Syndrome has been reported with serotonergic antidepressants (SSRIs, SNRIs, and others), including with TRINTELLIX, both when taken alone, but especially when coadministered with other serotonergic agents (including triptans, tricyclic antidepressants, fentanyl, lithium, tramadol, tryptophan, buspirone, and St. John’s Wort).
- If such symptoms occur, discontinue TRINTELLIX and initiate supportive treatment.
- If concomitant use of TRINTELLIX with other serotonergic drugs is clinically warranted, patients should be made aware of a potential increased risk for serotonin syndrome, particularly during treatment initiation and dose increases.
- Treatment with serotonergic antidepressants (SSRIs, SNRIs, and others) may increase the risk of abnormal bleeding.
- Patients should be cautioned about the increased risk of bleeding when TRINTELLIX is coadministered with nonsteroidal antiinflammatory drugs (NSAIDs), aspirin, or other drugs that affect coagulation. Activation of Mania/Hypomania can occur with antidepressant treatment.
- Screen patients for bipolar disorder.
- Angle Closure Glaucoma: Angle closure glaucoma has occurred in patients with untreated anatomically narrow angles treated with antidepressants.
- Hyponatremia can occur in association with the syndrome of inappropriate antidiuretic hormone secretion (SIADH)
