Fluvoxamine

What are the side effects of Luvox?

• were nausea,
• somnolence,
• insomnia,
• asthenia,
• nervousness,
• dyspepsia,
• abnormal ejaculation,
• sweating ,
• anorexia,
• tremor
• vomiting

Using the above rule, the following events were also identified: anorgasmia, decreased libido, dry mouth, rhinitis, taste perversion, and urinary frequency in patients with OCD; and agitation, depression, dysmenorrhea, flatulence, hyperkinesia, and rash in pediatric patients with OCD.

Drug Interactions (not described in Contraindications or Warnings And Precautions) include the following:

• Drugs Inhibiting or Metabolized by Cytochrome P450: Fluvoxamine inhibits several cytochrome P450 isoenzymes (CYP1A2, CYP2C9, CYP3A4, and CYP2C19).
• Carbamazepine: Elevated carbamazepine levels and symptoms of toxicity with coadministration (7.2).
• Sumatriptan: Rare postmarketing reports of weakness, hyperreflexia, and incoordination following use of an SSRI and sumatriptan. Monitor appropriately if concomitant treatment is clinically warranted (7.2).
• Tacrine: Coadministration increased tacrine Cmax and AUC five- and eightfold and caused nausea, vomiting, sweating, and diarrhea (7.2).
• Tricyclic Antidepressants (TCAs): Coadministration significantly increased plasma TCA levels. Use caution; monitor plasma TCA levels; reduce TCA dose if indicated (7.2).
• Tryptophan: Severe vomiting with coadministration (7.2).
• Diltiazem: Bradycardia with coadministration (7.3).
• Propranolol or metoprolol: Reduce dose if coadministered and titrate more cautiously (7.3).

• Suicidality: Monitor for clinical worsening and suicide risk

• Bipolar disorder: Screen for bipolar disorder

• Other potentially important drug interactions. Benzodiazepines: Use with caution. Coadministration with diazepam is generally not advisable • Clozapine: Clozapine levels may be increased and produce orthostatic hypotension or seizures

• Methadone: Coadministration may produce opioid intoxication. Discontinuation of fluvoxamine may produce opioid withdrawal

• Mexiletine: Monitor serum mexiletine levels

• Antipsychotics: Rare reports of neuroleptic malignant syndrome (NMS) or NMS-like events with and without coadministration of antipsychotics. If such events occur, discontinue fluvoxamine and any antipsychotic treatment immediately and initiate supportive measures

• Ramelteon: Should not be used in combination with fluvoxamine

• Theophylline: Clearance decreased; reduce theophylline dose by one-third

• Warfarin: Plasma concentrations increased and prothrombin times prolonged; monitor prothrombin time and adjust warfarin dose accordingly

• Other Drugs Affecting Hemostasis: Increased risk of bleeding with concomitant use of nsaids, aspirin, or other drugs affecting coagulation

• Serotonin Syndrome: May occur with concomitant use of fluvoxamine with serotonergic drugs, including triptans, and drugs that impair serotonin metabolism. See Contraindications (4).