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Uses
Side effects
Interactions
Precautions
- WAKIX is a histamine-3 (H3) receptor antagonist/inverse agonist indicated for the treatment of excessive daytime sleepiness (EDS) in adult patients with narcolepsy.
- The most common adverse reactions (≥5% and twice placebo) for WAKIX were insomnia, nausea, and anxiety.
- Strong CYP2D6 Inhibitors: Maximum recommended dosage is 17.8 mg once daily
- Strong CYP3A4 Inducers: Decreased exposure of WAKIX; consider dosage adjustment
Sensitive CYP3A4 Substrates (including hormonal contraceptives): - WAKIX may reduce effectiveness of sensitive CYP3A4 substrates. Use an alternative non-hormonal contraceptive method during treatment with WAKIX and for at least 21 days after discontinuation of treatment.
- The most common adverse reactions (≥5% and twice placebo) for WAKIX were insomnia, nausea, and anxiety.
